PE-22-28

What is PE-22-28 and how does it work?

PE-22-28 is a 7-amino acid derivative of Spadin, which blocks the TREK-1 channel in the brain. Chronic, unpredictable mild stress increases TREK-1 in the hippocampus, a region that controls mood, memory, and learning. The TREK-1 increase may allow for stress-induced cognitive impairment and low mood, so blocking it seems to preserve cognitive performance and mood during stress. Mice studies showed that PE-22-28 reduced immobility time and delay to eating food. It also boosts neuronal growth and connections, and protects neurons from excitotoxicity.

Benefits and uses:

  • Improves mood and motivation

  • Induces neurogenesis and synaptogenesis

  • Improves firing rates of serotonin neurons

  • Protects neurons from excess glutamate

  • Improves the brain’s stress resilience

  • Preserves cognitive performance amidst stress

Stacks well with:

  • Pinealon

  • Epithalon

  • BPC-157

  • Thymosin beta 4 (TB500)

  • Semax