MOTS-c

What is MOTS-c and how does it work?

MOTS-c is a 16-amino acid mitochondrial peptide produced mainly in muscles. It’s also detectable in other tissues and in the blood

Exercise generally boosts MOTS-c levels, so MOTS-c administration replicates many of the benefits of exercise.

Benefits and uses:

  • Protects the cells

  • Maintains mitochondrial function and cellular viability under stressful conditions

  • Regulates metabolic homeostasis

  • May mitigate diet-induced insulin resistance and obesity

  • Inhibits purine biosynthesis

  • Activates 5’adenosine monophosphate-activated protein kinase (AMPK), increasing fat oxidation

  • Increases transport of fatty acids into the mitochondria to burn for energy

  • Increases fat burning and reduces production of new fat molecules

  • Improves glucose uptake by bringing glucose transporter 4 (Glut4) in muscles

  • Activates peroxisome proliferator-activated receptor-gamma coactivator (PGC-1alpha), which increases the generation of new and healthy mitochondria.

  • PGC-1alpha then activates nuclear respiratory factors (Nrf1 and Nrf2), which turns on many antioxidant genes.

  • Increases calorie burn as heat production by increasing brown fat and mitochondrial uncoupling using uncoupling protein 1 (UCP-1)

  • Preserves mitochondrial function and bone mass in a mouse menopause model, with biochemical effects similar to exercise

  • Improves athletic performance

  • Supports weight loss effort in combination with diet and exercise

  • May improve strength and muscle gain by modulating myostatin

  • Protects against memory impairment from amyloid beta and lipopolysaccharides (inflammatory bacterial toxins from leaky gut) in a mouse model with intranasal delivery

  • May boost longevity

Stacks well with:

  • BPC-157

  • Thymosin beta 4 (TB500)

  • Thymosin alpha 1

  • Humanin

  • NAD+

Ways to take:

  • Subcutaneous injections

  • Intravenous push

Return to the full list of peptides offered at Kona Integrative Health