LL-37
What is LL-37 and how does it work?
LL-37 is the 37-amino acid cleavage product of human cathelicidin, an antiviral, antimicrobial, and anti-biofilm peptide. Humans produce the precursor form of this peptide in our neutrophils, natural killer cells, and in the lung lining cells.
Because LL-37 is positively charged, it can cling to and poke holes in negatively-charged bacterial cells and viral membranes. It can block the bacterial toxin called lipopolysaccharides from causing inflammation through Toll-like receptors. With its interaction with cell membranes, it can help modulate immune function.
Benefits and uses:
Help fights some infections, especially respiratory
Blocks lipopolysaccharides from interacting with TLR4 receptors, so it can mitigate metabolic endotoxemia, and inflammation from high-fat meals and gram-negative bacteria
Reduces Th2 cytokines
Protects against gut inflammation from gut infections
Helps call other immune cells to the site
Promotes a balanced immune response
Inhibits macrophages’ fever-producing activities
Stacks well with:
Thymosin beta 4 (TB500)
BPC-157
Thymosin alpha 1.
Ways to take:
Subcutaneous injections
Intranasal
Return to the full list of peptides offered at Kona Integrative Health